Cell Fusion as a Route to Immortalized Antibody Production

Why fusing a naturally short-lived, one-antibody-producing B cell with an immortal but antibody-silent cancer cell combines the useful trait of each into one permanently dividing hybrid.

References

• Köhler, G., Milstein, C. "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity." Nature 256, no. 5517 (1975): 495–497.