Bisulfite Sequencing

Maps bisulfite-protected cytosines genome-wide at base resolution by chemically converting unprotected cytosines into a different base before sequencing.

References

• Frommer, M., McDonald, L.E., Millar, D.S., et al. "A Genomic Sequencing Protocol That Yields a Positive Display of 5-Methylcytosine Residues in Individual DNA Strands." Proceedings of the National Academy of Sciences 89, no. 5 (1992): 1827–1831.