Differential Scanning Fluorimetry

Screens protein stability quickly across many samples by tracking a dye's fluorescence as it binds newly exposed hydrophobic surface during heat-induced unfolding.

References

• Niesen, F.H., Berglund, H., Vedadi, M. "The Use of Differential Scanning Fluorimetry to Detect Ligand-Binding Stability of Proteins." Nature Protocols 2, no. 9 (2007): 2212–2221.