Free-Solution Electrophoretic Separation in a Capillary

Why confining a high-voltage separation to a very narrow capillary, rather than a wide gel slab, allows far higher field strengths and correspondingly sharper, faster separation.

References

• Jorgenson, J.W., Lukacs, K.D. "Zone Electrophoresis in Open-Tubular Glass Capillaries." Analytical Chemistry 53, no. 8 (1981): 1298–1302.