Generating a Permanent, Renewable Source of One Specific Antibody

A single, well-defined antibody with known specificity needs a permanent, renewable production source, rather than a finite, exhaustible supply from a naturally short-lived cell.

References

• Köhler, G., Milstein, C. "Continuous Cultures of Fused Cells." Nature 256, no. 5517 (1975): 495–497.