Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

Probes a protein's conformation and dynamics by measuring how quickly its backbone hydrogens swap for a heavier isotope, region by region.

References

• Englander, S.W., Mayne, L. "The Nature of Protein Folding." Proceedings of the National Academy of Sciences 111, no. 45 (2014): 15873–15880.