Homology Modeling

Predicts an unknown protein's three-dimensional structure by borrowing directly from a related protein's already-solved structure, on the well-supported principle that similar sequences fold into similar shapes.

References

• Marti-Renom, M.A., Stuart, A.C., Fiser, A., et al. "Comparative Protein Structure Modeling of Genes and Genomes." Annual Review of Biophysics and Biomolecular Structure 29 (2000): 291–325.