Hydrogen-Deuterium Exchange & Protein Dynamics

Why a protein's backbone hydrogens swap with solvent at rates set by local structure, turning solvent exchange into a readout of folding and flexibility.

References

• Englander, S.W., Kallenbach, N.R. "Hydrogen Exchange and Structural Dynamics of Proteins and Nucleic Acids." Quarterly Reviews of Biophysics 16, no. 4 (1983): 521–655.