Identifying Conserved Positions Across a Sequence Family

Which positions across an entire family of related sequences stay evolutionarily conserved, and which tolerate change freely, need to be identified from the sequences together, not one pair at a time.

References

• Altschul, S.F., Gish, W., Miller, W., et al. "Basic Local Alignment Search." Journal of Molecular Biology 215, no. 3 (1990): 403–410.