Mapping Which Genomic Regions Physically Contact Each Other in 3D

The genome's folded, three-dimensional organization inside the nucleus needs to be mapped, since linear sequence alone says nothing about which distant regions actually sit near each other.

References

• Lieberman-Aiden, E., van Berkum, N.L., Williams, L., et al. "Comprehensive Mapping of Long-Range Interactions." Science 326, no. 5950 (2009): 289–293.