Modeling an Organ's Multi-Cell-Type Architecture in Culture
A research question needs to be studied in a three-dimensional, multi-cell-type tissue context, which a simple flat, single-cell-type culture can't provide.
References
- Sato, T., Vries, R.G., Snippert, H.J., et al. "Single Lgr5 Stem Cells." Cell 142, no. 1 (2010): 39–50.