RNA-Guided DNA Cleavage

How pairing a cutting enzyme with a short, redesignable guide RNA lets that enzyme be redirected to cut any chosen DNA sequence.

References

• Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J.A., Charpentier, E. "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity." Science 337, no. 6096 (2012): 816–821.