RNA Interference & Sequence-Specific Silencing

How a short RNA sequence, used purely as a base-pairing guide, directs a cellular complex to find and destroy one specific matching messenger RNA.

References

• Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., Mello, C.C. "Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans." Nature 391, no. 6669 (1998): 806–811.