RNAi Knockdown (siRNA/shRNA)

Reduces a specific gene's expression by introducing a short RNA sequence that directs cellular machinery to destroy that gene's own messenger RNA.

References

• Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., Tuschl, T. "Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells." Nature 411, no. 6836 (2001): 494–498.