Protein-Based DNA Targeting Through a Modular Binding Code

How stringing together repeating protein modules, each recognizing just one DNA base, builds a custom protein that binds one specific target sequence and directs cutting there.

References

• Christian, M., Cermak, T., Doyle, E.L., et al. "Targeting DNA Double-Strand Breaks." Nature Biotechnology 28, no. 12 (2010): 1299–1305.