Vitrification & Cryogenic Sample Preservation

How rapid vitrification traps hydrated specimens in amorphous ice, preserving near-native structure while avoiding the damage caused by crystalline ice.

References

• Dubochet, J., Adrian, M., Chang, J.J., Homo, J.C., Lepault, J., McDowall, A.W., Schultz, P. "Cryo-Electron Microscopy of Vitrified Specimens." Quarterly Reviews of Biophysics 21, no. 2 (1988): 129–228.